CNR I.E.O.M.I.

Institute of  Endotypes in Oncology, Metabolism and Immunology “G. Salvatore” – IEOMI 

On the basis of recent activites and ongoing projects, the scientific areas are based on the characterization of molecular and cellular mechanisms involved in the development of different pathologies.  This approach is defined as the study of endotypes, intended as the correlation and integration between genetic-epigenetic issues and environmental/phenotypic aspects mainly described from non-coding RNA profiles, as well as lipid, carbohydrate and protein profiles (including post-translational, PTMs).The general objectives include the identification of pathology markers, both for diagnostics and monitoring and also for target therapies, integrating fundamental and applied research.

These activities will increasingly have to be developed in a systems vision (Systems Biology/Medicine) to be able to strive for a more personalized medicine.

Based on the expertise acquired and the need for their evolution, the scientific areas of intervention  concern the study of:

Oncology  - including the characterization in the  carcinogenesis of proliferation, differentiation and cell death, of subcellular structures with the development of new drugs, biosensors and vectors.

Metabolism – including the characterization of molecular and cellular mechanisms that have a role in the development of metabolic diseases and the relationships between lifestyles, obesity, development of diabetes and associated complications.

Immunolgia -  including the characterization of molecular/cellular mechanisms underlying immune-mediated disorders and the role of the immune system in disease.

The general areas described above, although diversified by origin and environmental context, are interconnected with each other and shared by pathogenetic  and metabolic alterations.

An important part of the activity of the Institute regards the infrastructures BBMRI, for the collection and distribution of biological material and Eurobioimaging, specialized in the various aspects of microscopy and live imaging.  The combination of high resolution images of cellular structures with omic analysis, also supported  by the collaboration with IR Elixir, will allow to increase the precision of  molecular-cellular profiles (Precision Medicine).  Furthermore, the participation in BBMRI will permit the Institute to integrate its cellular models (2D and 3D) and animals, with human  specimens (real life).

The two IR  will place the Institute in a favorable competitive position, the must be exploited and developed in the near future.

Finally, activities already  underway  in the Institute will continue be developed  and have made public through Communication to the population of ongoing research, the Dissemination of Information of the results and their  Use (Exploitation) in the scientific community and territory.